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Showing posts with label damage. Show all posts
Showing posts with label damage. Show all posts

Tuesday, October 13, 2015

Rodent Feeding Studies Proving Harm To Bodily Functions

I'm pleased to report that Monsanto's stock is sliding down the crapper at a fantastic speed.






Here's a tidbit from GMO Free Canada's Facebook page:


GMO Free Canada's photo.




Over 40 rodent feeding studies find harm using varieties of genetically modified foods that are on the market today (Roundup Ready or Bt toxin insecticide producing).


Harmful effects included: Stomach barrier damage, increased risk of intestinal infections, high cholesterol, high blood sugar; reproductive issues including lower birth weight and increased mortality of offspring; organ disturbances in the pancreas, liver, kidneys, adrenal glands, ovaries and testes; other disturbances including disturbances to the immune system, blood biochemistry and functioning of the digestive system.


No wonder there is no consensus on the safety of GMO foods. We need to know if it's GMO.


1. E. Abdo, et al. “Feeding Study with Bt Corn (MON810: Ajeeb YG) on Rats: Biochemical Analysis and Liver Histopathology,” Food and Nutrition Sciences, Vol. 5 No. 2, 2014, pp. 185-195.
2. Battistelli S., Baldelli B., Malatesta M. (2008), Influence of a GMO-containing diet on pancreatic acinar cells of adult mice: effects of a short-term diet reversion, “Microscopie”, 10, pp. 36-43
3. S. Battistelli, B.Citterio, B. Baldelli, C. Parlani, and M. Malatesta (2010) Histochemical and morpho-metrical study of mouse intestine epithelium after a long term diet containing genetically modified soybean Eur J Histochem. September 26;54(3): e36
4. Brasil FB, Soares LL, Faria TS, Boaventura GT, Sampaio FJ, Ramos CF.(2009) The impact of dietary organic and transgenic soy on the reproductive system of female adult rat. Anat Rec(Hoboken).292(4):587594.
5. B Cisterna, F Flach, L Vecchio, SML Barabino, S Battistelli, TE Martin, M Malatesta, M Biggiogera (2008) Can a genetically modified organism-containing diet influence embryonic development? A preliminary study on pre- implantation mouse embryos. Cisterna.Vol.52(4)
6. Joël Spiroux de Vendômois, François Roullier, Dominique Cellier, Gilles-Eric Séralini (2009) A Comparison of the Effects of Three GM Corn Varieties on Mammalian Health Int J Biol Sci; 5(7):706-726.
7. O. P. Dolaychuk, R. S. Fedoruk (2013) Biological Effects of Different Levels of Soybeans Conventional and Transgenic Varieties in the Second-Generation Female Rats Ration. The Animal Biology, 2013, vol. 15, no. 2
8. Thanaa A. El-Kholy, Mohammad Abu Hilal, Hatim Ali Al-Abbadi, Abdulhalim Salim Serafi, Ahmad K. Al-Ghamdi, Hanan M. Sobhy and John R. C. Richardson (2014) The Effect of Extra Virgin Olive Oil and Soybean on DNA, Cytogenicity and Some Antioxidant Enzymes in Rats. Nutrients, 6(6), 2376-2386
9. El-Shamei ZS et al. Histopathological changes in some organs of male rats fed on genetically modified corn (Ajeeb YG). J Am Sci. 2012;8(10):684–696.
10. Ermakova IV (2006) Genetically modified soy leads to weight loss and increased mortality of pups of the first generation. Preliminary studies. EkosInform. Federal Environmental Law Gazette. a | -1,, p. 4-10.
11. Ermakova IV (2007) New data on the impact of GMOs on
physiological state and the higher nervous activities mammals. All-Russia Symposium TRANSGENIC PLANTS AND BIOSAFETY Moscow, October 22 - 25, pages 38-39
12. Irina Ermakova (2007) GM soybeans—revisiting a controversial format NATURE BIOTECHNOLOGY VOLUME 25 NUMBER 12 DECEMBER 1351-1354
13. Ermakova IV, IV Barskov (2008) Study of the physiological and morphological parameters in rats and their offspring using a diet containing soybean transgenic EPSPS CP4 Biological sciences. 6. p.19-20.
14. Ermakova IV (2009) Influence of soybean gene EPSPS CP4 on the physiological state and reproductive functions of rats in the first two generations Contemporary Problems in Science and Education Number 5, p.15-20. http://www.science-education.ru/33-1224
15. Finamore A, Roselli M, Britti S, Monastra G, Ambra R, Turrini A, Mengheri E. (2008) Intestinal and peripheral immune response to MON810 maize ingestion in weaning and old mice. J Agric Food Chem. Dec 10;56(23):11533-9.
16. Gab-Alla AA et al. Morphological and biochemical changes in male rats fed on genetically modified corn (Ajeeb YG). J Am Sci. 2012;8(9):1117–1123.
17. Т. V. Gorbach, I. U. Kuzminа, G. I. Gubina-Vakulik, N. G. Kolousova (2012) HORMONAL REGULATION OF SEXUAL FUNCTION AND OVARIAN HISTOLOGICAL FEATURES IN THE EXPERIMENT WITH GMO-SOYA USE IN FOOD. TAVRICHESKY LIFE SCIENCES BULLETIN 2012, Volume 15, № 2, Part 2 (58) pages 235-238
18. G.I. Gubin-Vakulik, S.A. Denisenko, T.V. Horbach, N.G. Kolousova, T.M. Popova (2012) MORPHOFUNCTIONAL STATE OF ADRENAL GLAND IN FEMALE RATS WISTAR WITH GENETICALLY MODIFIED SOY INCLUSION IN THE DIET. TAVRICHESKY LIFE SCIENCES BULLETIN 2012, Volume 15, № 3, Part 1 (59) pages 85-88
19. GI-Gubin VAKULIK TV, GORBACH BB, NG KOLOUSOVA HS, GOPKALOV (2013) THE METABOLIC AND HISTOLOGICAL CHANGES OF KIDNEYS IN FEMALE RATS AND THE FIRST GENERATION AFTER CONSUMPTION OF GENETICALLY MODIFIED SOYBEANS. SCIENTIFIC STATEMENTS Series Medicine. Pharmacy. 2013. № 11 (154). Issue 22 pages 150-155
20. G.I. Gubina-Vakulik, S.A. Denisenko, T.V. Gorbach, N.G. Kolousova, A.V. Andreev (2014) Morphofunctional Adrenal State in Adults Descendants With the Diet by Genetically Modified Soy. ЕКСПЕРИМЕНТАЛЬНА І КЛІНІЧНА МЕДИЦИНА. 2014. № 2 (63)
21. SERDAR KARAKUŞLU (2014) THE INVESTIGATION OF THE POTENTIAL EFFECTS OF GENETICALLY MODIFIED (GMO) MAIZE (Zea mays L.) ON SWISS ALBINO MICE. JUNE 2014, 25 Pages
22. Kiliç A, Akay MT. (2008) A three generation study with genetically modified Bt corn in rats: Biochemical and histopathological investigation. Food Chem Toxicol. 2008 Mar;46(3):1164-70.
23. Hasan Kiliçgün, Cebrail Gürsul, Mukadder Sunar, Gülden Gökşen (2013) The Comparative Effects of Genetically Modified Maize and Conventional Maize on Rats J Clin Anal Med ;4(2): 136-9
24. MA Konovalova, VA Blinov (2006) Influence of genetically modified soybean in mice and their offspring . Commercial Biotechnology 2006
25. Konovalova, MA, VA Blinov (2007) Morphometric parameters and features of the spectrum Blood enzymes mice receiving GENETICALLY MODIFIED SOY. All-Russia Symposium TRANSGENIC PLANTS AND BIOSAFETY Moscow, October 22 - 25, page 48
26. Konovalova MA, Potemkin EG (2007) Influence of genetically modified soybean on transport of carbohydrates in tissue.
27. Kuzmin, J. Yu, A. Kuzmin, and N. Pasieshvili (2012) Histological and Hormonal Features of Ovaries in an Experiment at Application of GMO-Soya in Nutrition. Journal of Research. 2012. № 4
28. Magaña-Gómez JA, Cervantes GL, Yepiz-Plascencia G, de la Barca AM. (2008) Pancreatic response of rats fed genetically modified soybean J Appl Toxicol. Mar;28(2):217-26.
29. Malatesta M, Caporaloni C, Gavaudan S, Rocchi MB, Serafini S, Tiberi C, Gazzanelli G. (2002) Ultrastructural morphometrical and immunocytochemical analyses of hepatocyte nuclei from mice fed on genetically modified soybean. Cell Struct Funct. Aug;27(4):173-80.
30. Manuela Malatesta, Chiara Caporaloni, Luigia Rossi, Serafina Battistelli, Marco BL Rocchi, Francesco Tonucci, and Giancarlo Gazzanelli (2002) Ultrastructural analysis of pancreatic acinar cells from mice fed on genetically modified soybean J Anat. November; 201(5): 409–415
31. Malatesta M., Biggiogera M., Manuali E., Rocchi M.B., Baldelli B., Gazzanelli G.(2003) Fine structural analysis of pancreatic acinar cell nuclei from mice fed on GM soybean. Eur J Histochem. 47,3858.
32. Malatesta M, Tiberi C, Baldelli B, Battistelli S, Manuali E, Biggiogera M. (2005) Reversibility of hepatocyte nuclear modifications in mice fed on genetically modified soybean. Eur J Histochem. Jul-Sep;49(3):237-42.
33. Malatesta M, Boraldi F, Annovi G, Baldelli B, Battistelli S, Biggiogera M, Quaglino D. (2008) A long-term study on female mice fed on a genetically modified soybean: effects on liver ageing. Histochem Cell Biol. Nov;130(5):967-77.
34. Maligin AG, Ermakova IV (2008) Soy diet suppresses reproductive function rodents. Modern problems of science and education № 6. (Annex "Biological sciences"). - C. 26
35. Nazarova AF, Ermakova IV (2010) Effect of soy diet on reproductive function and testosterone levels in rats and hamsters. Academy Trinitarism, № 77-6567, publ.15788, 12.02.
36. SG Nimbueva, R. Shirokov, SA Polyakov, SD Evgaldaev (2012) Influence of long term use of genetically modified soybeans on some morphofunctional indicators in pancreas of rats in the experiment. Articles XVII International Ecological Student Conference "Ecology Russia and adjacent territories ": in 2 volumes. Volume 2 / Novosibirsk State. Univ. Novosibirsk, 2012. Pages 119-120.
37. Oliveri et al (2006) Temporary depression of transcription in mouse preimplantation embryos from mice fed on genetically modified soybean. 48th Symposium of the Society for Histochemistry. Lake Maggiore(Italy), Sept.7- 10.
38. Hanaa ORABY, Mahrousa KANDIL, Nermeen SHAFFIE, Inas GHALY (2014) Biological impact of feeding rats with a genetically modified-based diet. Turk J Biol (2014) 38:
39. Séralini GE, Cellier D, de Vendomois JS.(2007) New analysis of a rat feeding study with a genetically modified maize reveals signs of hepatorenal toxicity. Arch Environ Contam Toxicol. May;52(4):596-602.

40. Gilles-Eric Séralini, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin and Joël Spiroux de Vendômois (2014) Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize. Environmental Sciences Europe , 26:14
41. AV Surov, NY Feoktistov, MV Ushakov, AV Gureeva (2010) Changing the physiological parameters of mammals feeding genetically modified ingredients of vegetable origin. Institution of the Russian Academy of Sciences Institute of Ecology and Evolution behalf ANSevertsov RAS (IEE RAS)
42. Vecchio L, Cisterna B, Malatesta M, Martin TE, Biggiogera M. (2004) Ultrastructural analysis of testes from mice fed on genetically modified soybean. Eur J Histochem. Oct-Dec;48(4):448-54.
43. Irena M Zdziarski, John W Edwards, Judy Carman, Adrian Jones, Marni Spillanie, Ysabella Van Sebille, Julie I Haynes (2012) GM feed and its effect on the stomach mucosa of rat. 6th Australian Health and Medical Research Congress 2012
44. ZHOU Ze-wei et al. (2012) Comprehensive Evaluation on Functions & Safety of Imported GM Soybean Using BDI-GS System Soybean Science Oct. Vol. 31 No 5
‪#‎gmo‬ ‪#‎health‬ ‪#‎labelgmos‬ ‪#‎needtoknowgmo‬ ‪#‎toxic‬ ‪#‎Bttoxin‬ ‪#‎gmofreecanada‬ ‪#‎gmofreeusa‬

Friday, May 8, 2015

Get The Picture?

I met some of the people involved in MAMNYC a couple of days ago - I think the bioQUACKS are in deep trouble.

I have a great idea for them - they should appear at the UN with fruits and vegetables "malformed" by genetic engineering; for example, purple lemons, black oranges, blue lettuce...and so on. I hope they see this posting and take from it what works.

The images below are from https://www.facebook.com/GMOFreeUSA - these will make the point much better than my words:

















The last image calls for some discussion. I believe that most of us will test positive for glyphosate infection, so I wouldn't call for anyone to take this test, unless you have a lawsuit prepared. Rather, we need to determine a way to flush glyphosate and any other GMO-derived agents from our bodies.

I mentioned that I am suffering from an "incident" which had negatively affected my life for over THREE YEARS. What would be a better test to take would be a determination of the status of one's gut flora - from there we could determine the damage done to one's gastrointestinal tract. It would certainly provide me with some direction in regards to restoring my life back to a semblance of normalcy.

At any rate, let's think about May 23rd.

Thursday, January 22, 2015

New Study: Monsanto’s Herbicide Chemical Damages DNA (re-post from PatriotRising)

New Study: Monsanto’s Herbicide Chemical Damages DNA

Posted January 21, 2015 11:23 am by
Did Monsanto Know All Along?
DNA

A new peer-reviewed scientific study has found that soybean workers exposed to glyphosate suffer from DNA damage and elevated cell death. Adenine (A), cytosine (C), guanine (G), and thymine (T) are the components of nucleic acid that make up DNA, and biotech is making these important parts of our biology a mash-up that no sane person would ever want to experience.

Soybean workers in Brazil exposed to fungicides herbicides and insecticides (the main three chemical classifications used extensively by the biotech farming model) experienced an elevated level of cellular apoptosis, as well as remarkable DNA damage according to the Elsevier published, Mutation Research/Genetic Toxicology and Environmental Mutagenesis.
The research concentrated on Glyphosate and 2,4-D, two chemicals that practically cover all of the US farming landscape. Glyphosate alone is used doubly as often as it was five years ago, with more than 185 million pounds of glyphosate-based and Round Up ready chemicals sprayed on our crops annually. Most GM crops were made, in fact, to withstand Round Up chemicals specifically. (Interestingly, the USDA won’t even test for glyphosate regularly because it’s ‘too expensive.’)

The herbicide 2,4-D has been used even longer than glyphosate – since the 1940s in fact – so there is no telling just how saturated our soil, and water is with this particular chemical. (Agent Orange, used during the Vietnam war contained 2,4-D.)

Danieli Benedetti and others found that the widespread cultivation of GM soybeans in the State of Rio Grande do Sul (RS, Brazil), especially in the city of Espumoso is particularly toxic to farm workers there.

They find:

“. . .the comet assay in peripheral leukocytes and the buccal micronucleus (MN) cytome assay (BMCyt) in exfoliated buccal cells were used to assess the effects of exposures to pesticides in soybean farm workers from Espumoso.A total of 127 individuals, 81 exposed and 46 non-exposed controls, were evaluated. Comet assay and BMCyt (micronuclei and nuclear buds) data revealed DNA damage in soybean workers.

Cell death was also observed (condensed chromatin, karyorhectic, and karyolitic cells). Inhibition of non-specific choline esterase (BchE) was not observed in the workers. The trace element contents of buccal samples were analyzed by Particle-Induced X-ray Emission (PIXE). Higher concentrations of Mg, Al, Si, P, S, and Cl were observed in cells from workers. No associations with use of personal protective equipment, gender, or mode of application of pesticides were observed.


Our findings indicate the advisability of monitoring genetic toxicity in soybean farm workers exposed to pesticides.”
It isn’t just farm workers that need to be concerned, though. Research in the German journal Ithaca stumbled upon significant concentrations of glyphosate in the urine samples of city dwellers. Many of the participants in this study showed glyphosate levels in their blood and urine that were up to 20 times the allowable levels in drinking water.

Other Studies Agree – Pesticide Chemicals Damage DNA

Multiple studies prior to the Brazilian research just conducted have shown cytotoxic and DNA-damaging effects of glyphosate exposure. In one study, Koller and his colleagues found that:

“. . . lymphocytes and cells from internal organs indicate that epithelial cells are more susceptible to the cytotoxic and DNA-damaging properties of the herbicide and its formulation. Since we found genotoxic effects after short exposure to concentrations that correspond to a 450-fold dilution of spraying used in agriculture, our findings indicate that inhalation may cause DNA damage in exposed individuals.”
As Natural Society previously reported, another study found that it only takes 57 parts per million for Round Up to completely destroy human kidney cells. We kind of need our kidneys. Agricultural levels of glyphosate are often more than 200 times this level.

You have to assume Monsanto knew that its RoundUp chemicals would damage DNA. After all, they’ve hidden toxicity results before, saying that they were a ‘commercial secret.’

Approximately 92% of all soybeans grown in the US are GMO, which means they are grown with Round Up or glyphosate-containing chemicals, and the Koller study found that even smaller concentrations (.02%) of Monsanto’s best seller sprayed on our crops causes DNA damage.

That means you can dilute Round Up more than 98% and it will still damage your cells.

In what country is a company allowed to knowingly, purposefully, scientifically kill human DNA (and thus humans) and not be charged with murder, treason, or at the bare minimum the withholding of information? Oh, that’s right – America.

Sure, biotech companies will tell you that DNA gets damaged all the time – from UV rays, oxidation, medical X-rays, even environmental toxins which biotech doesn’t create, but hen they systemically market a product(s) that kills your cells – shouldn’t they be stopped?

Damaged DNA leads to cancer, faster aging, neurological disease and the break down of our organs. There are hundreds of pathological conditions which are caused by damaged DNA, not that we can’t take proactive steps to heal our DNA, but agencies which allow these products to stay on the market are an abomination.

Even 9th graders understand the importance of DNA, and while the human genome project that sequenced more than 100,00 genes stilldidn’t explain the whole picture of our genetic make-up, DNA is an essential part of it, and shouldn’t be damaged. You can revisit the basics of DNA, here.

This article originally appeared at Natural Society.

Tuesday, October 7, 2014

Monsanto's Roundup Linked to Cancer - Again (Re-Post from TruthOut)

Monsanto's Roundup Linked to Cancer - Again

Monday, 06 October 2014 09:19 By Jeff Ritterman, M.D., Truthout | News Analysis 
 



A brilliant and celebrated inventor, John Franz, gave us an herbicide, Roundup, which has changed the face of agriculture. This herbicide has become the foundation for an entirely novel approach to farming - biotech agriculture - that has expanded rapidly throughout the globe.
Monsanto makes seeds for soy, corn, canola, cotton, alfalfa and sugar beets that are genetically engineered to be tolerant to Roundup. The seeds are marketed in 120 countries. Throughout the world, Roundup is sprayed heavily as a weed killer without fear of damaging the cash crops, which have been engineered to survive the herbicide's effects.

"The change in how agriculture is produced has brought, frankly, a change in the profile of diseases. We've gone from a pretty healthy population to one with a high rate of cancer, birth defects and illnesses seldom seen before."

Roundup seemed, at first, to be the perfect herbicide. It blocks the ESPS synthase enzyme, which prevents the synthesis of amino acids that plants need for growth. Since animals don't have this enzyme, it was initially hypothesized that they would be safe from Roundup's effects.
Unfortunately, Roundup has now been shown to affect much more than the EPSP synthase enzyme. The herbicide has been proven to cause birth defects in vertebrates, including in humans, and it may also be the cause of a fatal kidney disease epidemic.
An increasing number of studies are now linking the herbicide to cancer.
Roundup Linked to Increased Cancer in "Soy Republic"

Roundup is now heavily sprayed in what is known as the "Soy Republic," an area of Latin America larger than the state of California. This region has undergone a profound transformation since genetically modified (GM) crops were first introduced in 1996. Some 125 million acres in Argentina, Brazil, Bolivia, Uruguay and Paraguay are now devoted to GM soy production.
Doctors serving these areas have documented an alarming increase in cancers. A group of dedicated physicians formed an organization, Doctors of Fumigated Towns. They held a national conference in August of 2010 in Córdoba, the center of Argentina's soy region. The Department of Medical Sciences of the National University at Córdoba sponsored the conference. An estimated 160 doctors from throughout the country attended.
Dr. Medardo Avila Vazquez, a pediatrician specializing in environmental health, explained his concerns:
"The change in how agriculture is produced has brought, frankly, a change in the profile of diseases. We've gone from a pretty healthy population to one with a high rate of cancer, birth defects and illnesses seldom seen before. What we have complained about for years was confirmed and especially what doctors say about the sprayed towns and areas affected by industrial agriculture. Cancer cases are multiplying as never before in areas with massive use of pesticides."
Dr. Avila Vazquez blamed the biotech agricultural corporations for placing their profits over the public's health:
"The tobacco companies denied the link between smoking and cancer, and took decades to recognize the truth. The biotech and agrochemical corporations are the same as the tobacco industry; they lie and favor business over the health of the population."
It was the health of the population that concerned Dr. Damian Verzeñassi, professor of social and environmental health from the National University at Rosario. In 2010, he began a house-to-house epidemiological study of 65,000 people in Santa Fe, also in Argentina's soy region. He found cancer rates two to four times higher than the national average, with increases in breast, prostate and lung cancers.
Dr. Verzeñassi commented on his findings: "Cancer has skyrocketed in the last fifteen years."
Much the same was found in Chaco, Argentina's poorest province. In 2012, two villages were compared, the heavily sprayed farming village of Avia Terai and the non-sprayed ranching village of Charadai. In the farming village, 31 percent of residents had a family member with cancer while only 3 percent of residents in the ranching village had one.
Carlos Fria lives in Avia Terai. He has complained about glyphosate spraying in close proximity to his home:
"If the wind changes, the agrochemicals come into the house. My uncle just died of cancer. My wife too, passed away from cancer. Now many, many people are dying of cancer. It didn't used to be like that. In my opinion, this has to do with the poison they put on the fields."
Roundup Linked to Lymphoma
Research has also been done in the United States, Canada, Europe, Australia and New Zealand investigating possible links between glyphosate, Roundup's active ingredient, and cancer. A large number of studies have focused on glyphosate's possible association with non-Hodgkin's lymphoma.
Scientists from the International Agency for Research on Cancer (IARC) have analyzed studies spanning almost three decades. The IARC is the branch of the World Health Organization that promotes cancer research. Scientists throughout the world with skills in epidemiology, laboratory sciences and biostatistics are brought together to identify the causes of cancer so that preventive measures may be instituted. The agency views cancers as linked, directly or indirectly, to environmental factors.

The research shows that Roundup is linked to a host of cancers in those living in the heavily sprayed regions of Latin America. It has also been linked to B cell lymphoma, and to brain cancer.

In April of 2014, scientists at the IARC published their review of twenty-five years of research on the relationship between pesticide exposure and non-Hodgkin's lymphoma. They found a positive association between organo-phosphorus herbicides, like glyphosate, and this cancer. The B cell lymphoma sub-type, in particular, was strongly associated with glyphosate exposure.
Roundup Linked to Brain Cancer

The linkage to lymphoma is the most recent research raising concerns about glyphosate's connection to cancer. Scientists from the Agency for Toxic Substances and Disease Registry, a branch of the US Department of Health and Human Services, specialize in illnesses caused by toxic substances. They published the results of the US Atlantic Coast Childhood Brain Cancer Study in 2009. Children with brain cancer from Florida, New Jersey, New York and Pennsylvania were compared to age matched controls. The researchers found that if either parent had been exposed to Roundup during the two years before the child's birth, the chances of the child developing brain cancer doubled.
Roundup and Cancer: Human Observations Summarized
The research shows that Roundup is linked to a host of cancers in those living in the heavily sprayed regions of Latin America. It has also been linked to B cell lymphoma, and to brain cancer.
While the epidemiological studies show close correlation, they cannot prove causality. The gold standard for scientific proof is a randomized controlled trial, which would be unethical in this instance. You cannot ethically expose humans to an herbicide. Scientists therefore use a variety of experimental models to assess cancer risk.
Roundup Causes DNA Damage, Errors During Cell Division
Cancer risk can be evaluated by experiments that measure Roundup's ability to induce DNA damage.
One of the initial steps in the development of cancers is often damage to our DNA. Each of our cells gets its operating instructions from its DNA. If the DNA is damaged, the faulty operating instructions can re-program cells to divide rapidly and chaotically. When this happens, cells become transformed into cancers.
A number of experiments have been done using various animal models, all showing the same results: after exposure to Roundup, cells exhibited DNA damage. This was true in fruit fly larvae, in mice, in the blood cells of the European eel and in the lymphocytes of cows.
Another experimental model that has been used to judge glyphosate's cancer risk focuses on the herbicide's impact on cell division. Cells are vulnerable to being turned into cancers if an error is made during this delicate process. In the process of cell division, the DNA must be copied precisely. Each daughter cell must receive from its parent cell an identical copy of the DNA. If a mistake is made, the daughter cells will receive faulty DNA copies. Cells with damaged DNA can turn into cancers.
In a 2004 study done at the National Scientific Research Center and the University of Pierre and Marie Curie in France, Roundup caused significant errors in the cell division of sea urchin embryos. The scientists commented that these abnormalities are hallmarks of cancer and delivered a particularly chilling warning: The concentration of Roundup needed to cause these errors was 500 to 4,000 times lower than the dose to which humans may be exposed by aerial spraying or handling of the herbicide.
Roundup Damages Human DNA
The most worrisome of the DNA studies are the ones that show DNA damage in humans.
Dr. Fernando Manas, a biologist at the National University of Rio Cuarto in Argentina, has been investigating the effects of pesticides for years. He believes that glyphosate spraying is causing cancer by inducing DNA damage. His research has documented genetic damage in those exposed. When Dr. Manas studied pesticide sprayers working in the soy industry in Córdoba, he found significantly more DNA damage in their lymphocytes than in those of an unexposed group of controls. Roundup was one of the most commonly used pesticides.

The pesticide sprayers in Córdoba, the Ecuadorians living in Sucumbíos, and the normal volunteers all developed Roundup-induced DNA damage in their lymphocytes.

Genetics researchers from the Pontifical Catholic University in Quito, Ecuador evaluated Ecuadorians living in the Sucumbíos district in northern Ecuador for evidence of DNA damage. This area was heavily sprayed with Roundup by the Colombian government to eradicate illicit crops. Those exposed to the herbicide developed a number of acute symptoms, including abdominal pain, vomiting, diarrhea, fever, heart palpitations, headaches, dizziness, numbness, insomnia, depression, shortness of breath, blurred vision, burning of eyes, blisters and rash. When compared to a control group, they also showed significantly more DNA damage.
Interestingly, scientists have known since 1998 that when normal human lymphocytes were exposed to Roundup in a test tube, the lymphocytes developed DNA damage.
The pesticide sprayers in Córdoba, the Ecuadorians living in Sucumbíos, and the normal volunteers all developed Roundup-induced DNA damage in their lymphocytes. A cancer of the lymphocytes is known as a "lymphoma," the very same type of cancer that the International Agency for Research on Cancer showed to be strongly associated with glyphosate exposure.
Roundup Boosts Cancer in Tissue Culture Studies
Another method that scientists have used to assess Roundup's cancer risk is to expose cells grown in "tissue culture" to the herbicide. Sheets of cells are grown on a small dish with nutrients. Glyphosate is added and its effects are observed.
In 2010, researchers in India exposed mouse skin cells grown in tissue culture to Roundup. When the herbicide was added, the cells became cancerous.
Scientists in Thailand studied the impact of Roundup on human estrogen-responsive breast cancer cells in tissue culture. They published their results in 2013. Hormone-responsive breast cancer cells are known to grow when exposed to estrogen. Roundup also stimulated these cells to grow. The herbicide was able to bind to the cancer's estrogen receptors, thus mimicking the effects of estrogen and accelerating tumor growth.
Roundup Causes Cancer in Test Animals
Roundup's effects have been assessed in studies with a variety of test animals for more than three decades.
One of the earliest studies was done in 1979-1981, under the auspices of the United Nations Environmental Program, the International Labor Organization and the World Health Organization. Rats exposed to low levels of the herbicide developed testicular cancer. A larger dose did not produce the cancer. Unfortunately, at the time of the experiment, it was not understood that certain substances have more potent effects at lower doses than at higher doses. The evaluators erroneously dismissed the results showing the low-dose effect.
In a study from the Institute of Biology at the University of Caen in France, researchers studied glyphosate's effects on rats. Originally published in 2012, the resulting report was retracted after the biotech agriculture industry complained. After extensive review failed to show any fraud or problem with the data, the report was re-published in 2014. In this study, Roundup was shown to double the incidence of mammary gland tumors. These cancers developed much faster in rats exposed to Roundup than in controls. There was also an increase in cancers of the pituitary gland.
Rounding Up the Evidence
Epidemiological studies in humans, in the soy regions of Argentina and in Europe, the United States, Canada, Australia and New Zealand have shown Roundup to be linked to an increase in cancer risk. There is a strong association between Roundup and B cell lymphoma, brain cancer and a variety of other cancers in those living in heavily sprayed areas.
In addition to these epidemiological observations, laboratory studies have shown that Roundup causes DNA damage, disturbs cell division, increases cancer growth in tissue culture and induces cancer when fed to test animals.
Proving Causality

Does the evidence linking Roundup to cancer prove causality? In the 1964 landmark Surgeon General's Report, which for the very first time linked tobacco to cancer, Surgeon General Dr. Luther Terry presented criteria for the establishment of a cause and effect relationship in a scientific study.
To meet Dr. Terry's criteria, an association must be strong, specific and consistent. Cause must precede effect. And the association must be biologically plausible.

Biotech agriculture's most powerful backer, it seems, is the government of the United States.

How well does the association between Roundup and cancer fit these criteria?
Roundup exposure is consistently and specifically associated with precancerous abnormalities in a wide variety of experimental settings. Epidemiological observations show a tight linkage between glyphosate and cancer. In the laboratory research, as well as in the epidemiological studies in the field, exposure to the herbicide precedes the development of the abnormalities. There are plausible biological mechanisms that explain how glyphosate can transform cells into cancers.
In citing the Surgeon General's report, Drs. Wild and Seber, in their highly regarded statistics textbook, Chance Encounters, provide an example of a strong association. If an "illness is four times as likely among people exposed to a possible cause as it is for those who are not exposed," the association is considered strong.
Most of the glyphosate exposure experiments and epidemiological observations show a doubling of cancer risk. This leaves some room for doubt.
But who, given the science, would want to expose their loved ones to Roundup?
The State of the Science vs. the Science of the State

Roundup has now been conclusively proven to cause birth defects and to be closely linked to cancer. If we do not want this herbicide to accumulate in our water, land, and food, we need to stop using it.

In the final sad irony, when the cancer cells reach their growth peak, they kill their host and die in the process.

The science is clear, but powerful economic interests have, thus far, prevailed. The executives of the biotech agricultural corporations and their backers have ignored or denied the science documenting Roundup's harm.
Biotech agriculture's most powerful backer, it seems, is the government of the United States.
This official policy was explained in a 2010 US State Department cable from former Secretary of State Hillary Clinton:
"Our biotech outreach objectives for 2010 are to increase access to, and markets for, biotech as a means to help address the underlying causes of the food crisis, and to promote agricultural technology's role in mitigating climate change and increasing biofuel production."
The US government has been willing to exercise its muscle in support of the biotech agricultural corporations.
In El Salvador, for example, the United States recently pressured the government to buy Monsanto's GM seeds or risk losing $277 million in development aid. El Salvador refused and stood firm, preferring to buy the seeds from its own struggling farmers.
Cancer's Lessons
There is a disturbing parallel between the exponential growth of biotech agriculture and the spread of a cancer in the human body.
Cancers are cells that reproduce rapidly and haphazardly with no regard for the greater good of the organism. Cancer cells consume valuable energy, starving out normal cells. They grow so wildly and so quickly that they crowd out their neighbors. They send off emissaries to start new cancer colonies. They make harmful substances that damage healthy cells. They spread relentlessly. In the final sad irony, when the cancer cells reach their growth peak, they kill their host and die in the process.
Like a cancer, biotech agriculture has crowded out its neighbors and is spreading relentlessly. Also like a cancer, it makes harmful substances. Roundup is one of them. As more acreage comes under GM cultivation, we can expect Roundup use to continue to increase.
Roundup kills plants, causes birth defects in vertebrates, and is linked to cancer. Can a living planet withstand the continuous assault from this poison any more than the human body can withstand the attack from an aggressive cancer?
Do we need to fight biotech agriculture with the same persistence, commitment and force that we bring to bear in battling cancers?
The author thanks Vivien Feyer for contributions to this article.
Copyright, Truthout. May not be reprinted without permission.

Jeff Ritterman, M.D.

Jeff Ritterman, M.D. is vice president of the board of directors of the SF Bay Chapter of Physicians for Social Responsibility. He is the retired chief of cardiology at Kaiser Richmond and a former Richmond, California, city councilman. Follow him on Twitter @JeffRitterman.
Who really thinks is a good idea to inundate soil with this POISON?!?


One person commented how "back-breaking" it is to simply pull weeds from the soil...well, sometimes, things take hard work, and there's no getting around it.


Tell me what YOU think.